Monoterpene Citral Derivatives as Potential Antimalarials
نویسندگان
چکیده
منابع مشابه
Synthesis and Antibacterial Activities of Citral Derivatives
Citral, a bioactive compound in Palmrose oil, although known to have antibacterial effect, has not been used in current drug research. Optimization of the lead structure could enhance the utility of this compound. Hence citral was modified using natural amino acids to produce the Schiff’s base, a potential pharmacophore and the corresponding amines. In this study, we report the synthesis of 9 S...
متن کاملThe Synthesis of Potential Antimalarials
The general hypothesis as to the mode of action of chemotherapeutic agents, which has been formulated by Fildes, Woods, McIlwain, and others (2), offers a rational and useful guide to the design of new drugs. Thus, bacteriostasis is pictured as caused by the blocking of reactions essential to growth by an inhibiting substance which has a structure similar to that of one of the normal enzymes or...
متن کاملQuinuclidine derivatives as potential antiparasitics.
There is an urgent need for the development of new drugs for the treatment of tropical parasitic diseases such as Chagas' disease and leishmaniasis. One potential drug target in the organisms that cause these diseases is sterol biosynthesis. This paper describes the design and synthesis of quinuclidine derivatives as potential inhibitors of a key enzyme in sterol biosynthesis, squalene synthase...
متن کاملRegioselective Synthesis and Biological Evaluation of 1-Hydroxyl Modified Ailanthinone Derivatives as Antimalarials
The triterpene quassinoid ailanthinone is a structurally intricate natural product possessing highly potent antimalarial activity against multidrug resistance plasmodium parasites. Although the mechanism of action of ailanthinone is not completely understood, it is presumed to disrupt regular ribosomal functions by inhibiting parasite protein synthesis. Natural scarcity and low solubility of ma...
متن کاملQuinol derivatives as potential trypanocidal agents
Quinols have been developed as a class of potential anti-cancer compounds. They are thought to act as double Michael acceptors, forming two covalent bonds to their target protein(s). Quinols have also been shown to have activity against the parasite Trypanosoma brucei, the causative organism of human African trypanosomiasis, but they demonstrated little selectivity over mammalian MRC5 cells in ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Natural Product Communications
سال: 2014
ISSN: 1934-578X,1555-9475
DOI: 10.1177/1934578x1400900303